Senior Medical Director

The Position

At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a  Senior Medical Director  to join our Clinical Sciences team and take a central role in pioneering the future of healthcare.  

As a  Senior  Medical Director,   you'll  be at the forefront of translating genetic insights into  innovative treatments for patients . Your work will  help drive the clinical development programs  for game-changing  therapies, starting with a  small molecule that targets  SLC6A19  – a  novel therapeutic target for the treatment of  chronic kidney disease  and phenylketonuria .    

Maze Therapeutics has an exciting pipeline spanning both rare and common renal, cardiac, and metabolic diseases. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.   

To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As a Senior Medical Director for one or more development programs, you will partner closely with cross-functional team members and other technical experts to design, conduct, and interpret the key clinical studies, including first-in-human and proof-of-concept trials. Your contributions will be highly visible and integral to the success of the Maze team.  

This position reports to  the Head of Clinical  Development .  

The Impact You’ll Have

• Lead the design, execution, and analysis of   clinical trials for  the  SLC6A19  program and other  early-stage  clinical   assets at Maze  

• Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs    

• Prepare and deliver scientific presentations  and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.  

• Engage with scientific thought leaders and  patient advocacy groups   to  gain insights to inform clinical development plans and  build awareness and enthusiasm for the Maze pipeline assets .  

• Partner with Clinical Development Operations to  identify  and select study investigators and sites and  b uild strong professional relationships with study investigators.  

• Partner with Clinical Development Operations to  identify , select, and oversee vendors and CROs to support program needs .  

• Develop and integrate  timelines and budgets  for  clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders .  

As a Senior Director , we also expect our leaders to demonstrate the following Leadership Competencies:

• Communication and Influence

• Builds communication channels across Maze for sharing information.  

• Influences Senior Management decisions through persuasive arguments.  

• Respectfully addresses differing opinions leading to support of decisions.  

• Teamwork and Collaboration

• Champions partnerships and connections across Maze.  

• Proactively addresses issues that could result in breakdown of team relationships.  

• Spotlights team and individual contributions in public forums.  

• Execution and Results

• Addresses gaps and leverages strengths to get  best  results.  

• Maintains a  steadying  presence and clarifies priorities during change.  

• Anticipates and removes barriers that put functional/corporate goals at risk.  

• Develop Others and Self

• Remove barriers to staff development and empowers them to make their own decisions.  

• Stays current on industry trends and keeps direct-reports prepared and responsive.  

What We’re Looking For

• MD  with  6 + years  of  drug development  industry experience .    

• Board eligibility/certification and clinical experience  in internal medicine  and/or  pediatrics.  Additional  clinical or research experience in  nephrology  or cardiometabolic diseases is preferred.  

• E xperience  as a clinical study medical monitor   

• Experience with the preparation and submission of  scientific publications,  study protocols ,  Investigator Brochures , and other clinical-regulatory documents.    

• Experience in the  planning and oversight  of early-stage and/or registration-enabling clinical development programs including CRO  and site  selection and relationship building with investigators/site study staff,  patient  advocacy groups, and other third parties   

• Demonstrated knowledge and experience  in  the desig n and conduct of  clinical trials  and clinical data analysis and interpretation , particularly Phase 2 trials .  

• Experience leading a cross-functional study team.  

• Committed to nurturing relationships with  investigators, site study staff, patient advocacy groups, and other third parties  to support  the clinical programs and broader Maze objectives .     

• Exceptional  organizational, analytical,  and communication skills, enabling you to translate corporate  objectives  into actionable plans that consistently deliver high-quality data on time and within budget.  

• A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.  

• Willingness to travel domestically and internationally  ( up to   20 %)  for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential  gatherings. ­  

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week.    

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $337,500 - 412,500. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

 

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